Nicotinamide Adenine Dinucleotide (NAD+) is an essential coenzyme found in all living cells, serving as the electron carrier in mitochondrial ATP production and substrate for SIRT1 longevity genes.
1. Biological Roles of NAD+
Age-Related NAD+ Depletion
By age 50, cellular NAD+ levels decline by over 50% compared to youth, contributing to mitochondrial decay, neuroinflammation, and reduced DNA repair capacity.
- Intravenous Infusions (250mg – 500mg): Direct IV delivery bypasses GI breakdown, accelerating cellular replenishment and reducing brain fog.
- Oral Precursors: Supplementing with Nicotinamide Mononucleotide (NMN) or Nicotinamide Riboside (NR) to maintain sustained cellular pools.